We're diving into part one of our discussion on GLP-1 agonists. We’ll explore what they are, recent research, and some important considerations for their use.
What Are Peptides?
First, let’s talk about peptides. Peptides are chains of amino acids, typically fewer than 45 in length. They play crucial roles in various physiological processes such as cell signaling, neurotransmission, and hormone regulation. Some common peptides in our bodies include:
Insulin: Produced by the pancreas, insulin regulates blood sugar levels by promoting glucose uptake into cells.
Oxytocin: Known as the "love hormone," oxytocin plays a role in social bonding, childbirth, and lactation.
Growth Hormone: Stimulates growth, muscle maintenance, and metabolism, especially during childhood.
In the world of integrative medicine, we also use growth hormone secretagogues, which help your body naturally secrete its own growth hormone. But today, our focus is on GLP-1.
What is GLP-1?
Glucagon-like peptide-1 (GLP-1) is a hormone secreted by the L cells in the intestine in response to food intake. It plays several important roles:
Stimulates Insulin Secretion: GLP-1 enhances insulin release when blood glucose levels are high, helping to regulate blood sugar.
Inhibits Glucagon Secretion: By reducing glucagon levels, GLP-1 helps lower blood sugar.
Slows Gastric Emptying: This leads to increased satiety and reduced appetite, which can be beneficial for weight management.
Cardiovascular Health: GLP-1 agonists have shown benefits for heart health and are often used in weight management protocols.
Using GLP-1 Agonists: The Right and Wrong Way
GLP-1 agonists have been used by integrative and functional medicine doctors for over a decade. These peptides, like all others, should be used with caution and care. Here are some key points to consider:
Cycling: Just like other peptides, GLP-1 agonists should be cycled. It’s not advisable to keep the "foot on the gas pedal" constantly. Cycling helps reduce side effects and allows the body to adjust.
Dosing: Start low and go slow. Increasing the dose too quickly can lead to more severe side effects.
Foundational Health: Before starting GLP-1 agonists, ensure that you have the four pillars of health in place—nutrition, movement, breathwork, and sleep. Peptides work better when these basics are covered.
Unfortunately, some providers may not be as knowledgeable about the proper use of peptides, leading to misuse and potential harm. For instance, I’ve seen cases where med spas prescribe GLP-1 agonists without proper guidance on protein intake or other important considerations, leading to dangerous outcomes like dehydration and kidney issues.
Why Proper Management is Crucial
You can get GLP-1 agonists like semaglutide (Ozempic) and tirzepatide (Mounjaro) from various sources, but it’s vital to work with a healthcare provider who understands how to use these peptides correctly. Proper management involves:
Education on Nutrition: Patients need to understand the importance of protein intake and maintaining muscle mass.
Monitoring and Support: Regular follow-ups to adjust dosing and manage any side effects.
Personalized Care: Tailoring the use of GLP-1 agonists to the individual’s unique health profile.
The New Generation: GIP and Beyond
GLP-1 isn’t the only player in this field. The next generation includes GIP (glucose-dependent insulinotropic peptide), which works similarly but also contributes to lipid metabolism and energy storage. Newer therapies combining GLP-1 and GIP agonists are emerging, offering even more potential benefits.
Key Takeaways
Before starting any peptide therapy, it’s essential to prepare your body. This includes:
Nutrition: Focus on a protein-rich diet with 30 grams of protein per meal.
Sleep: Ensure good quality sleep, and if you snore, consider a sleep study.
Stress Management: Incorporate breathwork, prayer, or meditation to reduce stress.
Exercise: Lift heavy weights to maintain muscle mass and combat insulin resistance.
Also, consider a liver cleanse and addressing gut health before starting GLP-1 therapy to optimize your results and minimize side effects.
Final Thoughts
Peptides like GLP-1 agonists are powerful tools for improving health, but they must be used correctly. If you or someone you know is considering GLP-1 therapy, share this information to ensure they’re approaching it safely and effectively.
Stay tuned for part two, where we’ll dive into microdosing GLP-1 for inflammation and autoimmune diseases, and whether this approach might be beneficial.
If you found this information helpful, please share it, and don’t forget to leave a review for the podcast. Together, we can spread the word about the proper use of peptides and help more people achieve optimal health.
Dr. Jen signing out—until next time!
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